STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
babam2BRISC and BRCA1 A complex member 2. (386 aa)    
Predicted Functional Partners:
babam1
BRISC and BRCA1 A complex member 1.
    
 0.999
Brcc3
BRCA1/BRCA2-containing complex, subunit 3.
    
 0.998
abraxas2
Abraxas 2, BRISC complex subunit.
    
 0.983
brca1
Uncharacterized protein.
    
 0.964
bard1
BRCA1 associated RING domain 1.
   
 0.942
uimc1
Uncharacterized protein.
    
 0.864
SHMT2
Serine hydroxymethyltransferase 2.
    
  0.760
shmt2
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
    
  0.760
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
    
 0.669
chek2
Checkpoint kinase 2.
    
 0.660
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.