STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hspd1Heat shock 60 protein 1; Belongs to the chaperonin (HSP60) family. (575 aa)    
Predicted Functional Partners:
hspe1
10 kDa heat shock protein, mitochondrial; Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per [...]
 
 
 0.999
hspa9
Heat shock protein 9; Belongs to the heat shock protein 70 family.
  
 0.992
grpel1
GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.
  
 0.938
cct8
Chaperonin containing TCP1, subunit 8 (theta).
   
 0.925
hspa5
Uncharacterized protein; Belongs to the heat shock protein 70 family.
  
 0.908
tcp1
T-complex 1.
   
 
 0.864
clpp
ATP-dependent Clp protease proteolytic subunit.
 
 
 0.822
CLPB
ClpB homolog, mitochondrial AAA ATPase chaperonin.
  
 
 0.817
atp5f1b
ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 0.788
LOC101169506
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.
   
 
 0.779
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.