slc4a3 protein (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

slc4a3

Anion exchange protein. (1241 aa)

Predicted Functional Partners:

slc12a1

0.555

slc9a6

0.540

slc9a3

0.513

LOC101165788

0.508

SLC24A2

0.508

LOC101168081

0.406

ENSORLP00000037007

0.404

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000037007	LOC101165788	ENSORLP00000037007	ENSORLP00000025773	Tyrosine-protein kinase receptor.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.423
ENSORLP00000037007	slc12a1	ENSORLP00000037007	ENSORLP00000003346	Tyrosine-protein kinase receptor.	Solute carrier family 12 member 1.	0.411
ENSORLP00000037007	slc4a3	ENSORLP00000037007	ENSORLP00000026546	Tyrosine-protein kinase receptor.	Anion exchange protein.	0.404
LOC101165788	ENSORLP00000037007	ENSORLP00000025773	ENSORLP00000037007	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Tyrosine-protein kinase receptor.	0.423
LOC101165788	slc12a1	ENSORLP00000025773	ENSORLP00000003346	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Solute carrier family 12 member 1.	0.507
LOC101165788	slc4a3	ENSORLP00000025773	ENSORLP00000026546	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Anion exchange protein.	0.508
LOC101165788	slc9a3	ENSORLP00000025773	ENSORLP00000011453	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.528
LOC101165788	slc9a6	ENSORLP00000025773	ENSORLP00000001919	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.569
LOC101168081	slc4a3	ENSORLP00000040470	ENSORLP00000026546	Alpha-carbonic anhydrase domain-containing protein; Belongs to the alpha-carbonic anhydrase family.	Anion exchange protein.	0.406
SLC24A2	slc12a1	ENSORLP00000036980	ENSORLP00000003346	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Solute carrier family 12 member 1.	0.507
SLC24A2	slc4a3	ENSORLP00000036980	ENSORLP00000026546	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Anion exchange protein.	0.508
SLC24A2	slc9a3	ENSORLP00000036980	ENSORLP00000011453	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.528
SLC24A2	slc9a6	ENSORLP00000036980	ENSORLP00000001919	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.569
slc12a1	ENSORLP00000037007	ENSORLP00000003346	ENSORLP00000037007	Solute carrier family 12 member 1.	Tyrosine-protein kinase receptor.	0.411
slc12a1	LOC101165788	ENSORLP00000003346	ENSORLP00000025773	Solute carrier family 12 member 1.	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.507
slc12a1	SLC24A2	ENSORLP00000003346	ENSORLP00000036980	Solute carrier family 12 member 1.	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.507
slc12a1	slc4a3	ENSORLP00000003346	ENSORLP00000026546	Solute carrier family 12 member 1.	Anion exchange protein.	0.555
slc12a1	slc9a3	ENSORLP00000003346	ENSORLP00000011453	Solute carrier family 12 member 1.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.475
slc12a1	slc9a6	ENSORLP00000003346	ENSORLP00000001919	Solute carrier family 12 member 1.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.487
slc4a3	ENSORLP00000037007	ENSORLP00000026546	ENSORLP00000037007	Anion exchange protein.	Tyrosine-protein kinase receptor.	0.404

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.966

expected number of edges:

10

PPI enrichment p-value:

2.65e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017185

Peptidyl-lysine hydroxylation

3 of 10

2.76

1.9

0.00034

GO:0030198

Extracellular matrix organization

5 of 235

1.61

1.47

0.00046

GO:0071230

Cellular response to amino acid stimulus

3 of 48

2.07

1.25

0.0041

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008475

Procollagen-lysine 5-dioxygenase activity

3 of 3

3.28

2.87

6.49e-06

GO:0005201

Extracellular matrix structural constituent

4 of 81

1.97

2.0

8.20e-05

GO:0031418

L-ascorbic acid binding

3 of 24

2.38

1.92

0.00024

GO:0050211

Procollagen galactosyltransferase activity

2 of 4

2.98

1.49

0.0020

GO:0005506

Iron ion binding

3 of 190

1.48

0.75

0.0259

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005581

Collagen trimer

5 of 50

2.28

3.55

7.33e-08

GO:0062023

Collagen-containing extracellular matrix

6 of 214

1.73

2.55

4.30e-07

GO:0098644

Complex of collagen trimers

3 of 13

2.64

2.55

1.86e-05

GO:0005583

Fibrillar collagen trimer

2 of 9

2.63

1.35

0.0035

GO:0005615

Extracellular space

6 of 1470

0.89

0.62

0.0080

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33543004

(2019) Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis.

6 of 52

2.34

3.98

1.06e-08

PMID:32384775

(2020) Genomic Identification, Evolution, and Expression Analysis of Collagen Genes Family in Water Buffalo during Lactation.

4 of 23

2.52

2.46

2.41e-05

PMID:33224464

(2020) Comprehensive proteomic atlas of skin biomatrix scaffolds reveals a supportive microenvironment for epidermal development.

4 of 55

2.14

1.75

0.00041

PMID:34901026

(2021) Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis.

4 of 90

1.93

1.35

0.0021

PMID:25514169

(2014) RNA-seq analysis of equine conceptus transcripts during embryo fixation and capsule disappearance.

3 of 22

2.41

1.34

0.0033

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13687

Banded collagen fibril, and Collagen biosynthesis and modifying enzymes

6 of 28

2.61

5.46

2.45e-11

CL:13729

Procollagen-lysine 5-dioxygenase activity, and Glycosyl transferase family 2

3 of 5

3.06

3.03

3.11e-06

CL:13688

Banded collagen fibril, and Collagen chain trimerization

3 of 20

2.46

2.16

8.80e-05

CL:13690

Mixed, incl. Banded collagen fibril, and TGF beta-induced protein/periostin

2 of 12

2.5

1.1

0.0096

CL:13938

Laminin interactions, and Collagen IV, non-collagenous

2 of 28

2.13

0.74

0.0418

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ecb04974

Protein digestion and absorption

5 of 92

2.01

3.02

2.90e-07

ecb00310

Lysine degradation

3 of 58

1.99

1.61

0.00064

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1650814

Collagen biosynthesis and modifying enzymes

9 of 99

2.24

6.77

1.71e-16

MAP-1474290

Collagen formation

9 of 111

2.19

6.55

2.28e-16

MAP-1474244

Extracellular matrix organization

9 of 350

1.69

3.62

3.52e-12

MAP-8948216

Collagen chain trimerization

3 of 44

2.11

1.62

0.00073

MAP-216083

Integrin cell surface interactions

3 of 69

1.92

1.35

0.0021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098644

Complex of collagen trimers

3 of 19

2.48

1.89

0.00030

GOCC:0005581

Collagen trimer

3 of 29

2.29

1.76

0.00048

GOCC:0005588

Collagen type V trimer

2 of 2

3.28

1.69

0.00091

GOCC:0030079

Light-harvesting complex, peripheral complex

2 of 4

2.98

1.58

0.0014

GOCC:0031012

Extracellular matrix

4 of 191

1.6

1.34

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01391

Collagen triple helix repeat (20 copies)

5 of 72

2.12

3.0

6.10e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044861

Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain

3 of 3

3.28

2.83

7.60e-06

IPR001006

Procollagen-lysine 5-dioxygenase, conserved site

3 of 3

3.28

2.83

7.60e-06

IPR008160

Collagen triple helix repeat

5 of 74

2.11

2.76

2.16e-06

IPR006620

Prolyl 4-hydroxylase, alpha subunit

3 of 16

2.55

2.02

0.00018

IPR005123

Oxoglutarate/iron-dependent dioxygenase

3 of 20

2.46

1.91

0.00027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00702

Prolyl 4-hydroxylase alpha subunit homologues.

3 of 16

2.55

2.19

8.47e-05

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