ube2m protein (Oryzias latipes) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ube2m

UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)

Predicted Functional Partners:

H2MG95_ORYLA

0.966

ubxn7

0.963

nae1

0.958

cul1

0.950

rnf7

0.911

LOC101162521

0.906

UBA3

0.906

ENSORLP00000027520

0.906

ENSORLP00000045836

0.906

dcun1d3

0.893

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027520	H2MG95_ORYLA	ENSORLP00000027520	ENSORLP00000017626	Ubiquitin-like domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.978
ENSORLP00000027520	LOC101162521	ENSORLP00000027520	ENSORLP00000009971	Ubiquitin-like domain-containing protein.	Ubiquitin-like modifier activating enzyme 3.	0.921
ENSORLP00000027520	UBA3	ENSORLP00000027520	ENSORLP00000016993	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.921
ENSORLP00000027520	cul1	ENSORLP00000027520	ENSORLP00000003749	Ubiquitin-like domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.968
ENSORLP00000027520	dcun1d3	ENSORLP00000027520	ENSORLP00000035950	Ubiquitin-like domain-containing protein.	DCN1-like protein.	0.798
ENSORLP00000027520	nae1	ENSORLP00000027520	ENSORLP00000006837	Ubiquitin-like domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.966
ENSORLP00000027520	rnf7	ENSORLP00000027520	ENSORLP00000014565	Ubiquitin-like domain-containing protein.	Ring finger protein 7.	0.935
ENSORLP00000027520	ube2m	ENSORLP00000027520	ENSORLP00000029012	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.906
ENSORLP00000027520	ubxn7	ENSORLP00000027520	ENSORLP00000031501	Ubiquitin-like domain-containing protein.	UBX domain protein 7.	0.981
ENSORLP00000045836	H2MG95_ORYLA	ENSORLP00000045836	ENSORLP00000017626	Ubiquitin-like domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.978
ENSORLP00000045836	LOC101162521	ENSORLP00000045836	ENSORLP00000009971	Ubiquitin-like domain-containing protein.	Ubiquitin-like modifier activating enzyme 3.	0.921
ENSORLP00000045836	UBA3	ENSORLP00000045836	ENSORLP00000016993	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.921
ENSORLP00000045836	cul1	ENSORLP00000045836	ENSORLP00000003749	Ubiquitin-like domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.968
ENSORLP00000045836	dcun1d3	ENSORLP00000045836	ENSORLP00000035950	Ubiquitin-like domain-containing protein.	DCN1-like protein.	0.798
ENSORLP00000045836	nae1	ENSORLP00000045836	ENSORLP00000006837	Ubiquitin-like domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.966
ENSORLP00000045836	rnf7	ENSORLP00000045836	ENSORLP00000014565	Ubiquitin-like domain-containing protein.	Ring finger protein 7.	0.935
ENSORLP00000045836	ube2m	ENSORLP00000045836	ENSORLP00000029012	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.906
ENSORLP00000045836	ubxn7	ENSORLP00000045836	ENSORLP00000031501	Ubiquitin-like domain-containing protein.	UBX domain protein 7.	0.981
H2MG95_ORYLA	ENSORLP00000027520	ENSORLP00000017626	ENSORLP00000027520	Ring-box 1, E3 ubiquitin protein ligase.	Ubiquitin-like domain-containing protein.	0.978
H2MG95_ORYLA	ENSORLP00000045836	ENSORLP00000017626	ENSORLP00000045836	Ring-box 1, E3 ubiquitin protein ligase.	Ubiquitin-like domain-containing protein.	0.978

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Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.798

expected number of edges:

10

PPI enrichment p-value:

0.096

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016331

Morphogenesis of embryonic epithelium

4 of 107

1.85

1.28

0.0027

GO:0002009

Morphogenesis of an epithelium

5 of 353

1.43

1.06

0.0033

GO:0060670

Branching involved in labyrinthine layer morphogenesis

2 of 8

2.68

1.05

0.0124

GO:0001843

Neural tube closure

3 of 66

1.94

1.01

0.0112

GO:0008544

Epidermis development

4 of 211

1.56

0.96

0.0093

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004252

Serine-type endopeptidase activity

5 of 180

1.72

1.85

6.81e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12518

MET Receptor Activation, and Delta-catenin binding

5 of 12

2.9

5.05

3.95e-10

CL:12521

MET Receptor Activation

4 of 6

3.1

4.21

2.00e-08

CL:12228

Transmembrane receptor protein tyrosine kinase signaling pathway, and GPVI-mediated activation cascade

6 of 157

1.86

2.92

1.41e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6806942

MET Receptor Activation

3 of 6

2.98

2.64

1.54e-05

MAP-8852405

Signaling by MST1

2 of 4

2.98

1.38

0.0032

MAP-6806834

Signaling by MET

3 of 78

1.86

1.22

0.0038

MAP-9006934

Signaling by Receptor Tyrosine Kinases

5 of 529

1.25

0.96

0.0032

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0420

Kringle

4 of 15

2.7

3.84

6.24e-08

KW-0720

Serine protease

4 of 94

1.91

2.14

2.85e-05

KW-0721

Serine protease homolog

2 of 2

3.28

2.12

0.00015

KW-1015

Disulfide bond

7 of 1202

1.04

7.41e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01390

SEA domain

2 of 11

2.54

0.75

0.0444

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038178

Kringle superfamily

4 of 15

2.7

3.5

2.90e-07

IPR018056

Kringle, conserved site

4 of 15

2.7

3.5

2.90e-07

IPR000001

Kringle

4 of 15

2.7

3.5

2.90e-07

IPR013806

Kringle-like fold

4 of 31

2.39

2.94

2.16e-06

IPR001254

Serine proteases, trypsin domain

6 of 137

1.92

2.9

2.90e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

4 of 15

2.7

3.83

6.48e-08

SM00020

Trypsin-like serine protease

6 of 138

1.92

3.21

3.49e-08

SM00473

Divergent subfamily of APPLE domains

2 of 3

3.1

1.75

0.00068

SM00059

Fibronectin type 2 domain

2 of 18

2.32

1.09

0.0096

SM00192

Low-density lipoprotein receptor domain class A

2 of 46

1.92

0.71

0.0454

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