STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
chek2Checkpoint kinase 2. (526 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 0.995
cdc25b
Rhodanese domain-containing protein.
   
 0.993
Atm
Uncharacterized protein.
    
 0.993
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
0.992
tp53bp1
Tumor protein p53 binding protein, 1.
    
 0.976
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.955
brca1
Uncharacterized protein.
   
 0.950
cdc7
Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily.
    
 
 0.938
ENSORLP00000027619
TAN domain-containing protein.
    
 0.938
mcm4
DNA helicase; Belongs to the MCM family.
   
 
 0.931
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.