pomt2 protein (Oryzias latipes) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

pomt2

Protein-O-mannosyltransferase 2. (742 aa)

Predicted Functional Partners:

pomt1

0.995

pomgnt1

0.965

Pomgnt2

0.965

dag1

0.804

LOC101165732

0.804

fkrp

0.692

fktn

0.683

pomk

0.664

gmppb

0.633

dpm3

0.629

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101165732	Pomgnt2	ENSORLP00000037673	ENSORLP00000036246	Peptidase S72 domain-containing protein.	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	0.910
LOC101165732	dag1	ENSORLP00000037673	ENSORLP00000013717	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.902
LOC101165732	fkrp	ENSORLP00000037673	ENSORLP00000008827	Peptidase S72 domain-containing protein.	Fukutin related protein.	0.497
LOC101165732	fktn	ENSORLP00000037673	ENSORLP00000023409	Peptidase S72 domain-containing protein.	Fukutin.	0.504
LOC101165732	pomgnt1	ENSORLP00000037673	ENSORLP00000016661	Peptidase S72 domain-containing protein.	Protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-).	0.794
LOC101165732	pomk	ENSORLP00000037673	ENSORLP00000035431	Peptidase S72 domain-containing protein.	Protein O-mannose kinase.	0.707
LOC101165732	pomt1	ENSORLP00000037673	ENSORLP00000020743	Peptidase S72 domain-containing protein.	Protein-O-mannosyltransferase 1.	0.814
LOC101165732	pomt2	ENSORLP00000037673	ENSORLP00000036698	Peptidase S72 domain-containing protein.	Protein-O-mannosyltransferase 2.	0.804
Pomgnt2	LOC101165732	ENSORLP00000036246	ENSORLP00000037673	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Peptidase S72 domain-containing protein.	0.910
Pomgnt2	dag1	ENSORLP00000036246	ENSORLP00000013717	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Dystroglycan 1.	0.910
Pomgnt2	dpm3	ENSORLP00000036246	ENSORLP00000000602	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.	0.558
Pomgnt2	fkrp	ENSORLP00000036246	ENSORLP00000008827	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Fukutin related protein.	0.662
Pomgnt2	fktn	ENSORLP00000036246	ENSORLP00000023409	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Fukutin.	0.662
Pomgnt2	gmppb	ENSORLP00000036246	ENSORLP00000021821	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	GDP-mannose pyrophosphorylase B.	0.560
Pomgnt2	pomgnt1	ENSORLP00000036246	ENSORLP00000016661	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-).	0.964
Pomgnt2	pomk	ENSORLP00000036246	ENSORLP00000035431	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Protein O-mannose kinase.	0.672
Pomgnt2	pomt1	ENSORLP00000036246	ENSORLP00000020743	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Protein-O-mannosyltransferase 1.	0.965
Pomgnt2	pomt2	ENSORLP00000036246	ENSORLP00000036698	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	Protein-O-mannosyltransferase 2.	0.965
dag1	LOC101165732	ENSORLP00000013717	ENSORLP00000037673	Dystroglycan 1.	Peptidase S72 domain-containing protein.	0.902
dag1	Pomgnt2	ENSORLP00000013717	ENSORLP00000036246	Dystroglycan 1.	Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-).	0.910

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Network Stats

number of nodes:

10

number of edges:

21

average node degree:

4.2

avg. local clustering coefficient:

0.873

expected number of edges:

9

PPI enrichment p-value:

0.000652

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0040019

Positive regulation of embryonic development

2 of 6

2.88

0.81

0.0391

GO:0045039

Protein insertion into mitochondrial inner membrane

2 of 8

2.76

0.8

0.0391

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 419

1.34

0.72

0.0279

GO:0098798

Mitochondrial protein-containing complex

3 of 267

1.41

0.65

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6513

Mixed, incl. Tim10-like, and Mitochondrial intermembrane space import and assembly protein 40

4 of 17

2.73

3.46

5.49e-07

CL:6519

TIM22 mitochondrial import inner membrane insertion complex, and Tim10-like

3 of 5

3.14

2.98

5.61e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

3 of 47

2.16

1.47

0.0019

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042719

Mitochondrial intermembrane space protein transporter complex

2 of 5

2.96

1.46

0.0028

GOCC:0098798

Mitochondrial protein complex

4 of 228

1.6

1.2

0.0028

GOCC:0005740

Mitochondrial envelope

4 of 383

1.38

1.05

0.0034

GOCC:0031967

Organelle envelope

5 of 547

1.32

1.03

0.0028

GOCC:0071013

Catalytic step 2 spliceosome

2 of 37

2.09

0.92

0.0215

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

2 of 20

2.36

1.05

0.0132

KW-0496

Mitochondrion

3 of 160

1.63

0.94

0.0132

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10312

Conserved mid region of cactin

2 of 2

3.36

1.51

0.0023

PF04621

PEA3 subfamily ETS-domain transcription factor N terminal domain

2 of 4

3.06

1.45

0.0029

PF02953

Tim10/DDP family zinc finger

2 of 6

2.88

1.39

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019134

Splicing factor Cactin, C-terminal

2 of 2

3.36

1.23

0.0073

IPR018816

Splicing factor cactin, central domain

2 of 2

3.36

1.23

0.0073

IPR006715

PEA3-type ETS-domain transcription factor, N-terminal

2 of 4

3.06

1.22

0.0073

IPR035427

Tim10-like domain superfamily

2 of 6

2.88

1.18

0.0085

IPR004217

Tim10-like

2 of 6

2.88

1.18

0.0085

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01050

Cactus-binding C-terminus of cactin protein

2 of 3

3.18

1.65

0.0013

SM00413

Erythroblast transformation specific domain

2 of 32

2.15

0.8

0.0372

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