STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101158223Insulin-degrading enzyme; Belongs to the peptidase M16 family. (1015 aa)    
Predicted Functional Partners:
LOC100125446
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.859
LOC101172253
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.859
rps27a
Ribosomal protein S27a.
    
 0.843
ubc
Ubiquitin B.
    
  0.814
LOC101172288
Amyloid beta (A4) precursor protein b.
    
 
 0.761
APP
Amyloid beta precursor protein.
    
 
 0.761
igf2
Insulin-like growth factor 2b.
    
 
 0.748
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
  0.729
H2M970_ORYLA
Ubiquitin-like domain-containing protein.
    
  0.729
LOC101166855
Transforming growth factor, alpha.
    
 
 0.698
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.