LOC101159384 protein (Oryzias latipes) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

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LOC101159384

Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family. (471 aa)

Predicted Functional Partners:

ADCYAP1

0.982

LOC101165591

0.981

LOC101163161

0.901

ghrh

0.803

vip

0.740

LOC101166988

0.583

crh

0.583

LOC101156047

0.524

ucn

0.520

LOC101155470

0.517

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1	LOC101159384	ENSORLP00000039459	ENSORLP00000040462	Adenylate cyclase activating polypeptide 1a.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.982
ADCYAP1	LOC101163161	ENSORLP00000039459	ENSORLP00000016315	Adenylate cyclase activating polypeptide 1a.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.982
ADCYAP1	LOC101165591	ENSORLP00000039459	ENSORLP00000043322	Adenylate cyclase activating polypeptide 1a.	Adenylate cyclase activating polypeptide 1b.	0.903
ADCYAP1	crh	ENSORLP00000039459	ENSORLP00000010676	Adenylate cyclase activating polypeptide 1a.	Corticotropin-releasing hormone.	0.505
ADCYAP1	ucn	ENSORLP00000039459	ENSORLP00000036699	Adenylate cyclase activating polypeptide 1a.	Urotensin 1.	0.436
LOC101155470	LOC101156047	ENSORLP00000042859	ENSORLP00000038587	Uncharacterized protein.	Uncharacterized protein.	0.973
LOC101155470	LOC101159384	ENSORLP00000042859	ENSORLP00000040462	Uncharacterized protein.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.517
LOC101155470	LOC101163161	ENSORLP00000042859	ENSORLP00000016315	Uncharacterized protein.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.517
LOC101156047	LOC101155470	ENSORLP00000038587	ENSORLP00000042859	Uncharacterized protein.	Uncharacterized protein.	0.973
LOC101156047	LOC101159384	ENSORLP00000038587	ENSORLP00000040462	Uncharacterized protein.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.524
LOC101156047	LOC101163161	ENSORLP00000038587	ENSORLP00000016315	Uncharacterized protein.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.524
LOC101159384	ADCYAP1	ENSORLP00000040462	ENSORLP00000039459	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1a.	0.982
LOC101159384	LOC101155470	ENSORLP00000040462	ENSORLP00000042859	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.517
LOC101159384	LOC101156047	ENSORLP00000040462	ENSORLP00000038587	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.524
LOC101159384	LOC101163161	ENSORLP00000040462	ENSORLP00000016315	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	0.901
LOC101159384	LOC101165591	ENSORLP00000040462	ENSORLP00000043322	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Adenylate cyclase activating polypeptide 1b.	0.981
LOC101159384	LOC101166988	ENSORLP00000040462	ENSORLP00000008562	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	CRF domain-containing protein.	0.583
LOC101159384	crh	ENSORLP00000040462	ENSORLP00000010676	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing hormone.	0.583
LOC101159384	ghrh	ENSORLP00000040462	ENSORLP00000028148	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Growth hormone releasing hormone.	0.803
LOC101159384	ucn	ENSORLP00000040462	ENSORLP00000036699	Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.	Urotensin 1.	0.520

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

10 of 48

2.46

9.16

7.24e-21

GO:0006428

isoleucyl-tRNA aminoacylation

3 of 4

3.02

3.37

6.93e-07

GO:0006433

prolyl-tRNA aminoacylation

2 of 2

3.14

2.06

0.00019

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

9 of 47

2.43

8.0

3.99e-18

GO:0002161

aminoacyl-tRNA editing activity

4 of 11

2.71

3.97

3.48e-08

GO:0004822

isoleucine-tRNA ligase activity

3 of 4

3.02

3.19

1.50e-06

GO:0004827

proline-tRNA ligase activity

2 of 2

3.14

2.12

0.00015

GO:0005524

ATP binding

9 of 1375

0.96

1.04

2.49e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8312

Selenoamino acid metabolism, and tRNA-binding domain

11 of 16

2.98

14.25

1.05e-28

CL:8314

Cytosolic tRNA aminoacylation

9 of 10

3.1

12.12

9.77e-24

CL:8319

tRNA synthetases class I (E and Q), anti-codon binding domain, and prolyl-tRNA aminoacylation

5 of 5

3.14

6.29

2.64e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

10 of 61

2.36

8.83

3.40e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-379716

Cytosolic tRNA aminoacylation

9 of 19

2.82

10.58

1.18e-21

MAP-379724

tRNA Aminoacylation

10 of 43

2.51

9.69

8.68e-22

MAP-2408522

Selenoamino acid metabolism

8 of 16

2.84

9.44

4.29e-19

MAP-72766

Translation

10 of 210

1.82

4.84

6.55e-16

MAP-71291

Metabolism of amino acids and derivatives

8 of 197

1.75

3.68

2.28e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 10

2.75

3.71

1.22e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

4 of 20

2.45

3.36

3.38e-07

KW-0648

Protein biosynthesis

4 of 53

2.02

2.57

4.14e-06

KW-0820

tRNA-binding

2 of 10

2.45

1.5

0.0017

KW-0067

ATP-binding

4 of 635

0.94

0.53

0.0349

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 7

2.78

2.4

3.97e-05

PF03950

tRNA synthetases class I (E and Q), anti-codon binding domain

2 of 2

3.14

1.54

0.0017

PF01588

Putative tRNA binding domain

2 of 4

2.84

1.41

0.0028

PF03129

Anticodon binding domain

2 of 7

2.6

1.26

0.0051

PF08264

Anticodon-binding domain of tRNA ligase

2 of 9

2.49

1.2

0.0062

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

6 of 60

2.14

3.8

7.64e-09

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

4 of 15

2.57

3.2

9.25e-07

IPR023586

Isoleucine-tRNA ligase, type 2

3 of 3

3.14

2.87

6.14e-06

IPR002301

Isoleucine-tRNA ligase

3 of 4

3.02

2.8

8.05e-06

IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

3 of 9

2.67

2.38

4.04e-05

(more ...)

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