STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (634 aa)    
Predicted Functional Partners:
pgr
Uncharacterized protein.
   
0.843
LOC101161140
Vitellogenin 3, phosvitinless.
   
  
 0.837
sp1
Sp1 transcription factor.
    
 0.806
nrip1
Nuclear receptor interacting protein 1b.
    
 0.795
cyp19b
Aromatase B; Belongs to the cytochrome P450 family.
    
 0.787
LOC101174651
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
    
 0.784
LOC101160197
E1A binding protein p300 a.
    
 0.768
LOC101168870
E1A binding protein p300 b.
    
 0.768
med1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.748
gper1
G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family.
    
 
 0.746
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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