STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ywhag14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)    
Predicted Functional Partners:
cdc25b
Rhodanese domain-containing protein.
    
 0.978
LOC101175099
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family.
  
0.782
LOC101165659
14_3_3 domain-containing protein; Belongs to the 14-3-3 family.
  
0.781
yap1
Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation.
    
 0.745
raf1
Raf-1 proto-oncogene, serine/threonine kinase a.
   
 0.717
araf
A-Raf proto-oncogene, serine/threonine kinase.
   
 0.717
braf
B-Raf proto-oncogene, serine/threonine kinase.
   
 0.717
ENSORLP00000041845
HECT domain-containing protein.
  
 
 0.681
TSC2
TSC complex subunit 2.
    
 0.650
Tsc2
DUF3384 domain-containing protein.
    
 0.650
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.