stx2 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

stx2

Syntaxin 2b; Belongs to the syntaxin family. (320 aa)

Predicted Functional Partners:

vamp4

0.973

Vamp3

0.944

snap23

0.942

LOC101173249

0.917

LOC101164413

0.917

vamp2

0.917

LOC101170749

0.915

snap25

0.915

vamp7

0.869

LOC105354787

0.868

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101164413	LOC101170749	ENSORLP00000026958	ENSORLP00000032772	Vesicle-associated membrane protein 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.941
LOC101164413	LOC101173249	ENSORLP00000026958	ENSORLP00000015396	Vesicle-associated membrane protein 1.	Zgc:92912.	0.546
LOC101164413	LOC105354787	ENSORLP00000026958	ENSORLP00000027156	Vesicle-associated membrane protein 1.	Vesicle-associated membrane protein 8 (endobrevin).	0.755
LOC101164413	Vamp3	ENSORLP00000026958	ENSORLP00000019936	Vesicle-associated membrane protein 1.	Vesicle-associated membrane protein 3 (cellubrevin).	0.889
LOC101164413	snap23	ENSORLP00000026958	ENSORLP00000014271	Vesicle-associated membrane protein 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.932
LOC101164413	snap25	ENSORLP00000026958	ENSORLP00000044155	Vesicle-associated membrane protein 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.941
LOC101164413	stx2	ENSORLP00000026958	ENSORLP00000043396	Vesicle-associated membrane protein 1.	Syntaxin 2b; Belongs to the syntaxin family.	0.917
LOC101164413	vamp2	ENSORLP00000026958	ENSORLP00000044147	Vesicle-associated membrane protein 1.	Vesicle-associated membrane protein 2.	0.561
LOC101164413	vamp4	ENSORLP00000026958	ENSORLP00000002367	Vesicle-associated membrane protein 1.	Vesicle-associated membrane protein 4.	0.913
LOC101164413	vamp7	ENSORLP00000026958	ENSORLP00000012845	Vesicle-associated membrane protein 1.	Synaptobrevin-like 1; Belongs to the synaptobrevin family.	0.814
LOC101170749	LOC101164413	ENSORLP00000032772	ENSORLP00000026958	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 1.	0.941
LOC101170749	LOC101173249	ENSORLP00000032772	ENSORLP00000015396	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Zgc:92912.	0.941
LOC101170749	LOC105354787	ENSORLP00000032772	ENSORLP00000027156	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 8 (endobrevin).	0.915
LOC101170749	Vamp3	ENSORLP00000032772	ENSORLP00000019936	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 3 (cellubrevin).	0.978
LOC101170749	snap23	ENSORLP00000032772	ENSORLP00000014271	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.593
LOC101170749	snap25	ENSORLP00000032772	ENSORLP00000044155	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.544
LOC101170749	stx2	ENSORLP00000032772	ENSORLP00000043396	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Syntaxin 2b; Belongs to the syntaxin family.	0.915
LOC101170749	vamp2	ENSORLP00000032772	ENSORLP00000044147	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 2.	0.941
LOC101170749	vamp4	ENSORLP00000032772	ENSORLP00000002367	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Vesicle-associated membrane protein 4.	0.870
LOC101170749	vamp7	ENSORLP00000032772	ENSORLP00000012845	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	Synaptobrevin-like 1; Belongs to the synaptobrevin family.	0.914

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.859

expected number of edges:

13

PPI enrichment p-value:

5.81e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007218

Neuropeptide signaling pathway

5 of 111

1.96

2.45

6.23e-06

GO:0007186

G protein-coupled receptor signaling pathway

11 of 1020

1.34

2.31

1.52e-11

GO:0007600

Sensory perception

4 of 347

1.37

0.8

0.0161

GO:0003008

System process

6 of 1127

1.03

0.74

0.0062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031681

G-protein beta-subunit binding

5 of 26

2.59

4.36

4.38e-09

GO:0001664

G protein-coupled receptor binding

4 of 194

1.62

1.31

0.0013

GO:0048018

Receptor ligand activity

5 of 421

1.38

1.16

0.0013

GO:0005515

Protein binding

11 of 6815

0.52

0.41

0.0013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 50

2.31

3.68

4.27e-08

GO:0030141

Secretory granule

3 of 149

1.61

1.08

0.0051

GO:0030425

Dendrite

4 of 389

1.32

0.99

0.0035

GO:0043679

Axon terminus

2 of 50

1.91

0.85

0.0241

GO:0005886

Plasma membrane

8 of 5191

0.5

0.31

0.0462

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21631

Mixed, incl. GTPase complex, and G protein-coupled amine receptor activity

7 of 147

1.99

3.86

9.47e-10

CL:22019

Galanin receptor activity, and Neuropeptide binding

4 of 15

2.73

3.83

7.03e-08

CL:21640

GTPase complex, and G protein-coupled amine receptor activity

6 of 115

2.03

3.51

1.53e-08

CL:21653

G beta:gamma signalling through BTK, and Amino terminal of the G-protein receptor rhodopsin

4 of 23

2.55

3.45

2.82e-07

CL:22023

Vertebrate endogenous opioids neuropeptide, and Neuropeptide binding

3 of 6

3.01

3.06

2.63e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04371

Apelin signaling pathway

5 of 208

1.69

2.15

6.51e-06

map04080

Neuroactive ligand-receptor interaction

6 of 706

1.24

1.34

4.05e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-202040

G-protein activation

8 of 38

2.63

8.11

4.57e-17

MAP-111885

Opioid Signalling

8 of 114

2.15

5.71

4.18e-14

MAP-418594

G alpha (i) signalling events

11 of 430

1.72

4.43

1.28e-16

MAP-392451

G beta:gamma signalling through PI3Kgamma

5 of 39

2.42

4.36

2.21e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

5 of 46

2.34

4.16

4.25e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 15

2.73

3.61

1.85e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0449

Lipoprotein

5 of 64

2.2

3.59

3.79e-08

KW-0807

Transducer

6 of 629

1.29

1.42

3.61e-05

KW-1003

Cell membrane

5 of 464

1.34

1.33

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01160

Vertebrate endogenous opioids neuropeptide

2 of 3

3.13

1.28

0.0050

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00224

G protein gamma subunit-like motifs

5 of 22

2.66

4.83

6.16e-10

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About