STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101159741Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4. (629 aa)    
Predicted Functional Partners:
mdm4
MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.
    
 0.733
DCAF7
DDB1 and CUL4 associated factor 7.
   
 
 0.658
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 0.619
aar2
AAR2 splicing factor.
      
 0.558
Atm
Uncharacterized protein.
    
 0.502
ENSORLP00000027619
TAN domain-containing protein.
    
 0.502
nrip2
Nuclear receptor interacting protein 2.
      
 0.485
ripk2
Receptor-interacting serine-threonine kinase 2.
    
 
 0.423
ubc
Ubiquitin B.
   
  0.415
rps27a
Ribosomal protein S27a.
   
  0.411
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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