ENSORLP00000044967 protein (Oryzias latipes)

Nodes:

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white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ENSORLP00000044967

Uncharacterized protein. (189 aa)

Predicted Functional Partners:

fau

0.758

LOC101160447

0.510

gle1

0.475

rps28

0.438

rps19

0.438

rps24

0.437

rps15

0.432

rps13

0.415

rps11

0.413

LOC101163979

0.409

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000044967	LOC101160447	ENSORLP00000044967	ENSORLP00000038127	Uncharacterized protein.	RAN binding protein 2.	0.510
ENSORLP00000044967	LOC101163979	ENSORLP00000044967	ENSORLP00000008847	Uncharacterized protein.	Anti-silencing function 1Ba histone chaperone.	0.409
ENSORLP00000044967	fau	ENSORLP00000044967	ENSORLP00000018903	Uncharacterized protein.	40S ribosomal protein S30.	0.758
ENSORLP00000044967	gle1	ENSORLP00000044967	ENSORLP00000025585	Uncharacterized protein.	Uncharacterized protein.	0.475
ENSORLP00000044967	rps11	ENSORLP00000044967	ENSORLP00000045243	Uncharacterized protein.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.413
ENSORLP00000044967	rps13	ENSORLP00000044967	ENSORLP00000001582	Uncharacterized protein.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.415
ENSORLP00000044967	rps15	ENSORLP00000044967	ENSORLP00000007032	Uncharacterized protein.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.432
ENSORLP00000044967	rps19	ENSORLP00000044967	ENSORLP00000041232	Uncharacterized protein.	Ribosomal protein S19.	0.438
ENSORLP00000044967	rps24	ENSORLP00000044967	ENSORLP00000008455	Uncharacterized protein.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.437
ENSORLP00000044967	rps28	ENSORLP00000044967	ENSORLP00000026142	Uncharacterized protein.	Ribosomal protein S28.	0.438
LOC101160447	ENSORLP00000044967	ENSORLP00000038127	ENSORLP00000044967	RAN binding protein 2.	Uncharacterized protein.	0.510
LOC101160447	gle1	ENSORLP00000038127	ENSORLP00000025585	RAN binding protein 2.	Uncharacterized protein.	0.978
LOC101160447	rps11	ENSORLP00000038127	ENSORLP00000045243	RAN binding protein 2.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.556
LOC101163979	ENSORLP00000044967	ENSORLP00000008847	ENSORLP00000044967	Anti-silencing function 1Ba histone chaperone.	Uncharacterized protein.	0.409
fau	ENSORLP00000044967	ENSORLP00000018903	ENSORLP00000044967	40S ribosomal protein S30.	Uncharacterized protein.	0.758
fau	rps11	ENSORLP00000018903	ENSORLP00000045243	40S ribosomal protein S30.	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.	0.999
fau	rps13	ENSORLP00000018903	ENSORLP00000001582	40S ribosomal protein S30.	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.	0.999
fau	rps15	ENSORLP00000018903	ENSORLP00000007032	40S ribosomal protein S30.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
fau	rps19	ENSORLP00000018903	ENSORLP00000041232	40S ribosomal protein S30.	Ribosomal protein S19.	0.999
fau	rps24	ENSORLP00000018903	ENSORLP00000008455	40S ribosomal protein S30.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.999

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042176

Regulation of protein catabolic process

5 of 28

2.18

3.49

5.69e-08

GO:0010498

Proteasomal protein catabolic process

8 of 142

1.67

3.21

2.81e-10

GO:0051603

Proteolysis involved in protein catabolic process

10 of 235

1.55

3.09

5.48e-12

GO:0006511

Ubiquitin-dependent protein catabolic process

9 of 208

1.56

2.94

8.65e-11

GO:0043248

Proteasome assembly

4 of 19

2.25

2.88

1.98e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

3 of 6

2.62

2.04

0.00017

GO:0004298

Threonine-type endopeptidase activity

2 of 5

2.53

0.92

0.0213

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000502

Proteasome complex

11 of 35

2.42

9.97

1.08e-23

GO:0005838

Proteasome regulatory particle

9 of 20

2.58

9.13

8.60e-20

GO:0008541

Proteasome regulatory particle, lid subcomplex

5 of 10

2.62

4.98

2.59e-10

GO:0008540

Proteasome regulatory particle, base subcomplex

4 of 9

2.57

3.75

7.23e-08

GO:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.33

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1460

Proteasome complex

11 of 33

2.45

10.08

1.23e-23

CL:1461

Proteasome complex

8 of 28

2.38

6.99

7.87e-16

CL:1463

Proteasome accessory complex

6 of 14

2.56

5.77

3.82e-12

CL:1516

Proteasome regulatory particle, lid subcomplex

3 of 5

2.7

2.67

1.17e-05

CL:1466

Proteasome accessory complex

3 of 9

2.45

2.33

4.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 40

2.36

9.72

6.99e-24

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 38

2.39

9.66

2.66e-23

MAP-1236975

Antigen processing-Cross presentation

11 of 39

2.37

9.6

2.66e-23

MAP-5689880

Ub-specific processing proteases

11 of 72

2.11

7.46

4.92e-21

MAP-5688426

Deubiquitination

11 of 101

1.96

6.29

1.20e-19

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 164

1.75

4.74

1.57e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 81

2.06

6.92

5.10e-20

GOCC:0005838

Proteasome regulatory particle

4 of 16

2.32

3.06

1.03e-06

GOCC:0008540

Proteasome regulatory particle, base subcomplex

3 of 8

2.5

2.45

2.54e-05

GOCC:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.24

0.0051

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0647

Proteasome

5 of 22

2.28

3.83

1.62e-08

KW-0645

Protease

3 of 107

1.37

0.69

0.0312

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

5 of 17

2.39

3.68

5.95e-08

IPR036390

Winged helix DNA-binding domain superfamily

5 of 60

1.84

2.27

9.12e-06

IPR005937

26S proteasome regulatory subunit P45-like

3 of 6

2.62

2.17

9.68e-05

IPR003960

ATPase, AAA-type, conserved site

3 of 21

2.08

1.44

0.0017

IPR003959

ATPase, AAA-type, core

3 of 38

1.82

1.08

0.0072

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

5 of 13

2.51

4.43

2.27e-09

SM00753

PCI/PINT associated module

2 of 4

2.62

1.37

0.0031

SM00382

ATPases associated with a variety of cellular activities

3 of 99

1.4

0.76

0.0218

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