STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSORLP00000045210HEPN domain-containing protein. (4255 aa)    
Predicted Functional Partners:
UBE3A
Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
   
 
 0.822
LOC101165876
Ubiquitin protein ligase E3A.
   
 
 0.820
incenp
Uncharacterized protein.
   
 0.789
aurkb
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.728
aurka
Aurora kinase A; Belongs to the protein kinase superfamily.
   
 0.728
atp5f1b
ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.
   
 0.687
cdca8
Cell division cycle associated 8.
   
 0.687
LOC101159282
Diablo, IAP-binding mitochondrial protein a.
    
 0.685
diablo
Diablo, IAP-binding mitochondrial protein a.
    
 0.685
apaf1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
   
 0.669
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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