Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
npc2Niemann-Pick disease, type C2. (164 aa)    
Predicted Functional Partners:
npc1
Niemann-Pick disease, type C1.
    
 0.989
NPC1L1
NPC1 like intracellular cholesterol transporter 1.
    
 0.987
ENSAPOP00000015128
Uncharacterized protein.
    
 0.893
scap
SREBF chaperone.
    
 0.893
nudt19
Nudix (nucleoside diphosphate linked moiety X)-type motif 19.
    
   0.868
stard3
StAR-related lipid transfer (START) domain containing 3.
      
 0.764
smpdl3a
Acid sphingomyelinase-like phosphodiesterase.
   
 
  0.709
ptchd4
Patched domain containing 4.
   
 
  0.705
PTCHD3
Patched domain containing 3.
   
 
  0.705
plekhd1
Pleckstrin homology domain containing, family D (with coiled-coil domains) member 1.
   
 
  0.705
Your Current Organism:
Acanthochromis polyacanthus
NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish
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