Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC110955260Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. (551 aa)    
Predicted Functional Partners:
LOC110958830
Nodal modulator.
   
 
 0.889
tmem147
Transmembrane protein 147.
    
 
 0.888
eprs1
Glutamyl-prolyl-tRNA synthetase.
   
   0.884
ccdc47
Coiled-coil domain containing 47.
    
 
 0.837
tmco1
Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling.
   
 
 0.833
sec61b
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
    
 
 0.769
ENSAPOP00000020429
ER membrane protein complex subunit 6.
    
 
 0.742
rpn2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]
   
   0.735
RPL27A
Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.
    
 
 0.729
rpl18a
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
    
   0.728
Your Current Organism:
Acanthochromis polyacanthus
NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish
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