ndrg4 protein (Acanthochromis polyacanthus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ndrg4

NDRG family member 4. (352 aa)

Predicted Functional Partners:

gins3

0.654

LOC110948029

0.570

LOC110962689

0.551

lnx2

0.545

cdk9

0.540

RNF207

0.536

ENSAPOP00000007888

0.520

dnajb11

0.500

LOC110951985

0.498

rnf11

0.495

Your Current Organism:

Acanthochromis polyacanthus

NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPOP00000007888	ndrg4	ENSAPOP00000007888	ENSAPOP00000002537	Cardiolipin synthase 1.	NDRG family member 4.	0.520
LOC110948029	LOC110962689	ENSAPOP00000028787	ENSAPOP00000027715	MYCN proto-oncogene, bHLH transcription factor.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.742
LOC110948029	ndrg4	ENSAPOP00000028787	ENSAPOP00000002537	MYCN proto-oncogene, bHLH transcription factor.	NDRG family member 4.	0.570
LOC110951985	cdk9	ENSAPOP00000032133	ENSAPOP00000010283	Mohawk homeobox b.	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	0.437
LOC110951985	ndrg4	ENSAPOP00000032133	ENSAPOP00000002537	Mohawk homeobox b.	NDRG family member 4.	0.498
LOC110951985	rnf11	ENSAPOP00000032133	ENSAPOP00000017296	Mohawk homeobox b.	Ring finger protein 11b.	0.513
LOC110962689	LOC110948029	ENSAPOP00000027715	ENSAPOP00000028787	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MYCN proto-oncogene, bHLH transcription factor.	0.742
LOC110962689	cdk9	ENSAPOP00000027715	ENSAPOP00000010283	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	0.947
LOC110962689	ndrg4	ENSAPOP00000027715	ENSAPOP00000002537	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	NDRG family member 4.	0.551
RNF207	gins3	ENSAPOP00000017092	ENSAPOP00000015908	Ring finger protein 207.	GINS complex subunit 3.	0.660
RNF207	ndrg4	ENSAPOP00000017092	ENSAPOP00000002537	Ring finger protein 207.	NDRG family member 4.	0.536
cdk9	LOC110951985	ENSAPOP00000010283	ENSAPOP00000032133	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Mohawk homeobox b.	0.437
cdk9	LOC110962689	ENSAPOP00000010283	ENSAPOP00000027715	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.947
cdk9	ndrg4	ENSAPOP00000010283	ENSAPOP00000002537	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	NDRG family member 4.	0.540
cdk9	rnf11	ENSAPOP00000010283	ENSAPOP00000017296	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Ring finger protein 11b.	0.498
dnajb11	ndrg4	ENSAPOP00000026600	ENSAPOP00000002537	DnaJ heat shock protein family (Hsp40) member B11.	NDRG family member 4.	0.500
gins3	RNF207	ENSAPOP00000015908	ENSAPOP00000017092	GINS complex subunit 3.	Ring finger protein 207.	0.660
gins3	ndrg4	ENSAPOP00000015908	ENSAPOP00000002537	GINS complex subunit 3.	NDRG family member 4.	0.654
lnx2	ndrg4	ENSAPOP00000020712	ENSAPOP00000002537	Ligand of numb-protein X 2a.	NDRG family member 4.	0.545
ndrg4	ENSAPOP00000007888	ENSAPOP00000002537	ENSAPOP00000007888	NDRG family member 4.	Cardiolipin synthase 1.	0.520