Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC110964075Ubiquitin carboxyl-terminal hydrolase. (220 aa)    
Predicted Functional Partners:
ENSAPOP00000003675
Ubiquitin-like domain-containing protein.
    
 0.915
rps27a
Ribosomal protein S27a.
    
 0.900
LOC110955684
Ubiquitin-like domain-containing protein.
   
 0.890
LOC110953269
NEDD8 ubiquitin like modifier.
   
 0.890
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.883
CLPB
ClpB homolog, mitochondrial AAA ATPase chaperonin.
   
   0.790
usp14
Ubiquitin carboxyl-terminal hydrolase.
   
  
 0.780
prkn
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 
 0.778
psmd14
Proteasome 26S subunit, non-ATPase 14.
   
 0.773
LOC110962689
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.767
Your Current Organism:
Acanthochromis polyacanthus
NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish
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