chek2 protein (Acanthochromis polyacanthus) - STRING interaction network

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[Homology]

Score

chek2

Checkpoint kinase 2. (467 aa)

Predicted Functional Partners:

LOC110962689

0.999

atm

0.999

brca1

0.998

atr

0.997

CDC25B

0.996

tp53bp1

0.993

chek1

0.992

mdm2

0.991

LOC110948645

0.975

prkdc

0.967

Your Current Organism:

Acanthochromis polyacanthus

NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25B	LOC110962689	ENSAPOP00000023594	ENSAPOP00000027715	Cell division cycle 25B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.659
CDC25B	atm	ENSAPOP00000023594	ENSAPOP00000028362	Cell division cycle 25B.	Non-specific serine/threonine protein kinase.	0.714
CDC25B	atr	ENSAPOP00000023594	ENSAPOP00000008350	Cell division cycle 25B.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.961
CDC25B	brca1	ENSAPOP00000023594	ENSAPOP00000023730	Cell division cycle 25B.	Uncharacterized protein.	0.564
CDC25B	chek1	ENSAPOP00000023594	ENSAPOP00000010984	Cell division cycle 25B.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.995
CDC25B	chek2	ENSAPOP00000023594	ENSAPOP00000004912	Cell division cycle 25B.	Checkpoint kinase 2.	0.996
LOC110948645	LOC110962689	ENSAPOP00000011589	ENSAPOP00000027715	BRCA1 associated RING domain 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.993
LOC110948645	atm	ENSAPOP00000011589	ENSAPOP00000028362	BRCA1 associated RING domain 1.	Non-specific serine/threonine protein kinase.	0.980
LOC110948645	atr	ENSAPOP00000011589	ENSAPOP00000008350	BRCA1 associated RING domain 1.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.965
LOC110948645	brca1	ENSAPOP00000011589	ENSAPOP00000023730	BRCA1 associated RING domain 1.	Uncharacterized protein.	0.999
LOC110948645	chek1	ENSAPOP00000011589	ENSAPOP00000010984	BRCA1 associated RING domain 1.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.945
LOC110948645	chek2	ENSAPOP00000011589	ENSAPOP00000004912	BRCA1 associated RING domain 1.	Checkpoint kinase 2.	0.975
LOC110948645	mdm2	ENSAPOP00000011589	ENSAPOP00000019354	BRCA1 associated RING domain 1.	MDM2 proto-oncogene.	0.564
LOC110948645	prkdc	ENSAPOP00000011589	ENSAPOP00000006823	BRCA1 associated RING domain 1.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.755
LOC110948645	tp53bp1	ENSAPOP00000011589	ENSAPOP00000006674	BRCA1 associated RING domain 1.	Tumor protein p53 binding protein, 1.	0.960
LOC110962689	CDC25B	ENSAPOP00000027715	ENSAPOP00000023594	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cell division cycle 25B.	0.659
LOC110962689	LOC110948645	ENSAPOP00000027715	ENSAPOP00000011589	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BRCA1 associated RING domain 1.	0.993
LOC110962689	atm	ENSAPOP00000027715	ENSAPOP00000028362	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Non-specific serine/threonine protein kinase.	0.999
LOC110962689	atr	ENSAPOP00000027715	ENSAPOP00000008350	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
LOC110962689	brca1	ENSAPOP00000027715	ENSAPOP00000023730	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.998