STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC110952885NUMB like endocytic adaptor protein. (760 aa)    
Predicted Functional Partners:
LOC110968412
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
 0.949
LOC110957121
Notch receptor 1b.
    
 0.912
LOC110954188
Notch receptor 1a.
    
 0.912
LOC110965747
Notch receptor 3.
    
 0.898
LOC110958453
Notch receptor 2.
    
 0.892
gak
Cyclin G associated kinase.
   
 
 0.842
numb
NUMB endocytic adaptor protein.
  
  
 
0.828
LOC110963920
E3 ubiquitin-protein ligase.
    
 0.816
LOC110968687
E3 ubiquitin-protein ligase.
    
 0.816
mdm2
MDM2 proto-oncogene.
    
 
 0.802
Your Current Organism:
Acanthochromis polyacanthus
NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.