Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
brip1BRCA1 interacting protein C-terminal helicase 1. (1400 aa)    
Predicted Functional Partners:
brca1
Uncharacterized protein.
   
 0.991
pms2
PMS1 homolog 2, mismatch repair system component.
   
 0.990
mlh1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
   
 0.990
topbp1
DNA topoisomerase II binding protein 1.
   
 0.989
LOC110948645
BRCA1 associated RING domain 1.
  
 0.978
brca2
BRCA2 DNA repair associated.
   
 0.975
nbn
Nibrin.
    
 0.959
LOC110948070
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae).
  
 0.958
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 0.953
slf1
SMC5-SMC6 complex localization factor 1.
  
 0.948
Your Current Organism:
Acanthochromis polyacanthus
NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish
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