Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
LOC110965232Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (394 aa)    
Predicted Functional Partners:
psenen
Presenilin enhancer, gamma-secretase subunit.
    
 0.998
LOC110951636
APH1B gamma secretase subunit.
   
 0.995
NCSTN
Nicastrin.
   
 0.994
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.986
LOC110957121
Notch receptor 1b.
    
 0.976
LOC110954188
Notch receptor 1a.
    
 0.976
LOC110962813
Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.
    
 0.959
LOC110953660
Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.
    
 0.959
gsk3b
Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.
    
 0.959
LOC110957012
Uncharacterized protein.
    
 0.954
Your Current Organism:
Acanthochromis polyacanthus
NCBI taxonomy Id: 80966
Other names: A. polyacanthus, Acanthochromis polyacathus, spiny chromis, spiny damselfish
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