LOC111577187 protein (Amphiprion ocellaris) - STRING interaction network

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LOC111577187

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)

Predicted Functional Partners:

chek2

0.999

atm

0.999

chek1

0.999

sirt1

0.998

bax

0.998

atr

0.998

mdm4

0.997

LOC111570317

0.997

LOC111574397

0.997

brca1

0.996

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111570317	LOC111574397	ENSAOCP00000014681	ENSAOCP00000016355	E1A binding protein p300 b.	E1A binding protein p300 a.	0.901
LOC111570317	LOC111577187	ENSAOCP00000014681	ENSAOCP00000001385	E1A binding protein p300 b.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.997
LOC111570317	brca1	ENSAOCP00000014681	ENSAOCP00000000481	E1A binding protein p300 b.	Uncharacterized protein.	0.913
LOC111570317	mdm4	ENSAOCP00000014681	ENSAOCP00000009207	E1A binding protein p300 b.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.486
LOC111570317	sirt1	ENSAOCP00000014681	ENSAOCP00000020439	E1A binding protein p300 b.	Sirtuin 1.	0.919
LOC111574397	LOC111570317	ENSAOCP00000016355	ENSAOCP00000014681	E1A binding protein p300 a.	E1A binding protein p300 b.	0.901
LOC111574397	LOC111577187	ENSAOCP00000016355	ENSAOCP00000001385	E1A binding protein p300 a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.997
LOC111574397	brca1	ENSAOCP00000016355	ENSAOCP00000000481	E1A binding protein p300 a.	Uncharacterized protein.	0.913
LOC111574397	mdm4	ENSAOCP00000016355	ENSAOCP00000009207	E1A binding protein p300 a.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.486
LOC111574397	sirt1	ENSAOCP00000016355	ENSAOCP00000020439	E1A binding protein p300 a.	Sirtuin 1.	0.919
LOC111577187	LOC111570317	ENSAOCP00000001385	ENSAOCP00000014681	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	E1A binding protein p300 b.	0.997
LOC111577187	LOC111574397	ENSAOCP00000001385	ENSAOCP00000016355	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	E1A binding protein p300 a.	0.997
LOC111577187	atm	ENSAOCP00000001385	ENSAOCP00000019655	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Non-specific serine/threonine protein kinase.	0.999
LOC111577187	atr	ENSAOCP00000001385	ENSAOCP00000029053	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
LOC111577187	bax	ENSAOCP00000001385	ENSAOCP00000028487	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BCL2 associated X, apoptosis regulator a.	0.998
LOC111577187	brca1	ENSAOCP00000001385	ENSAOCP00000000481	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.996
LOC111577187	chek1	ENSAOCP00000001385	ENSAOCP00000022231	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.999
LOC111577187	chek2	ENSAOCP00000001385	ENSAOCP00000002373	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 2.	0.999
LOC111577187	mdm4	ENSAOCP00000001385	ENSAOCP00000009207	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.997
LOC111577187	sirt1	ENSAOCP00000001385	ENSAOCP00000020439	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Sirtuin 1.	0.998

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