Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fbxo22F-box protein 22. (387 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1; Belongs to the SKP1 family.
    
 0.990
cul1
Cullin 1b; Belongs to the cullin family.
    
 0.985
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.931
LOC111577551
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.
     
  0.901
nfkbia
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.
     
  0.901
LOC111577187
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.737
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.700
LOC111579028
CULLIN_2 domain-containing protein; Belongs to the cullin family.
    
 0.700
bach2
BTB and CNC homology 1, basic leucine zipper transcription factor 2b.
    
 
 0.689
LOC111575881
Uncharacterized protein.
    
 
 0.689
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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