Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (833 aa)    
Predicted Functional Partners:
mcm3
DNA helicase; Belongs to the MCM family.
   
0.990
LOC111586609
Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.
   
0.989
mcm5
DNA helicase; Belongs to the MCM family.
   
0.989
mcm7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
0.987
mcm4
DNA helicase; Belongs to the MCM family.
   
0.987
mcm2
DNA helicase; Belongs to the MCM family.
   
0.975
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.970
cdt1
Chromatin licensing and DNA replication factor 1.
   
 0.960
orc2
Origin recognition complex, subunit 2.
   
 0.951
mcm10
Minichromosome maintenance 10 replication initiation factor.
   
 0.938
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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