Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)    
Predicted Functional Partners:
ccnd1
Cyclin D1; Belongs to the cyclin family.
   
 0.997
LOC111582895
Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4).
    
 0.989
rb1
Retinoblastoma 1.
   
 0.984
ENSAOCP00000016161
Cyclin D2, a; Belongs to the cyclin family.
   
 0.982
ccnd2
Cyclin D2, b; Belongs to the cyclin family.
   
 0.982
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.981
LOC111574372
Cyclin-dependent kinase inhibitor 1A.
   
 0.981
ENSAOCP00000018881
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4).
   
 0.976
rbl1
Retinoblastoma-like 1 (p107).
   
 0.974
LOC111586657
Retinoblastoma-like 2 (p130).
   
 0.974
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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