chek2 protein (Amphiprion ocellaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25B	LOC111577187	ENSAOCP00000003125	ENSAOCP00000001385	Cell division cycle 25B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.551
CDC25B	atm	ENSAOCP00000003125	ENSAOCP00000019655	Cell division cycle 25B.	Non-specific serine/threonine protein kinase.	0.651
CDC25B	atr	ENSAOCP00000003125	ENSAOCP00000029053	Cell division cycle 25B.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.933
CDC25B	brca1	ENSAOCP00000003125	ENSAOCP00000000481	Cell division cycle 25B.	Uncharacterized protein.	0.481
CDC25B	chek1	ENSAOCP00000003125	ENSAOCP00000022231	Cell division cycle 25B.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.998
CDC25B	chek2	ENSAOCP00000003125	ENSAOCP00000002373	Cell division cycle 25B.	Checkpoint kinase 2.	0.999
LOC111577187	CDC25B	ENSAOCP00000001385	ENSAOCP00000003125	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cell division cycle 25B.	0.551
LOC111577187	LOC111583696	ENSAOCP00000001385	ENSAOCP00000004420	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tumor protein p53 binding protein, 1.	0.986
LOC111577187	LOC111586407	ENSAOCP00000001385	ENSAOCP00000004156	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.	0.988
LOC111577187	atm	ENSAOCP00000001385	ENSAOCP00000019655	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Non-specific serine/threonine protein kinase.	0.999
LOC111577187	atr	ENSAOCP00000001385	ENSAOCP00000029053	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
LOC111577187	bard1	ENSAOCP00000001385	ENSAOCP00000008446	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	BRCA1 associated RING domain 1.	0.987
LOC111577187	brca1	ENSAOCP00000001385	ENSAOCP00000000481	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.996
LOC111577187	chek1	ENSAOCP00000001385	ENSAOCP00000022231	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.999
LOC111577187	chek2	ENSAOCP00000001385	ENSAOCP00000002373	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 2.	0.999
LOC111577187	prkdc	ENSAOCP00000001385	ENSAOCP00000009219	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.983
LOC111583696	LOC111577187	ENSAOCP00000004420	ENSAOCP00000001385	Tumor protein p53 binding protein, 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.986
LOC111583696	atm	ENSAOCP00000004420	ENSAOCP00000019655	Tumor protein p53 binding protein, 1.	Non-specific serine/threonine protein kinase.	0.996
LOC111583696	atr	ENSAOCP00000004420	ENSAOCP00000029053	Tumor protein p53 binding protein, 1.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.942
LOC111583696	bard1	ENSAOCP00000004420	ENSAOCP00000008446	Tumor protein p53 binding protein, 1.	BRCA1 associated RING domain 1.	0.927