APP protein (Amphiprion ocellaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

APP

Amyloid beta precursor protein. (779 aa)

Predicted Functional Partners:

sorl1

0.924

NCSTN

0.909

ide

0.895

tnfrsf21

0.886

pitrm1

0.861

LOC111585205

0.767

gulp1

0.750

psenen

0.737

LOC111573543

0.725

LOC111583303

0.725

Your Current Organism:

Amphiprion ocellaris

NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LOC111573543	ENSAOCP00000003099	ENSAOCP00000022531	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.725
APP	LOC111583303	ENSAOCP00000003099	ENSAOCP00000030051	Amyloid beta precursor protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.725
APP	LOC111585205	ENSAOCP00000003099	ENSAOCP00000020398	Amyloid beta precursor protein.	Uncharacterized protein; Belongs to the synuclein family.	0.767
APP	NCSTN	ENSAOCP00000003099	ENSAOCP00000018114	Amyloid beta precursor protein.	Nicastrin.	0.909
APP	gulp1	ENSAOCP00000003099	ENSAOCP00000004272	Amyloid beta precursor protein.	GULP PTB domain containing engulfment adaptor 1a.	0.750
APP	ide	ENSAOCP00000003099	ENSAOCP00000010970	Amyloid beta precursor protein.	Insulin-degrading enzyme; Belongs to the peptidase M16 family.	0.895
APP	pitrm1	ENSAOCP00000003099	ENSAOCP00000019601	Amyloid beta precursor protein.	Pitrilysin metallopeptidase 1.	0.861
APP	psenen	ENSAOCP00000003099	ENSAOCP00000002996	Amyloid beta precursor protein.	Presenilin enhancer, gamma-secretase subunit.	0.737
APP	sorl1	ENSAOCP00000003099	ENSAOCP00000030664	Amyloid beta precursor protein.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.924
APP	tnfrsf21	ENSAOCP00000003099	ENSAOCP00000011177	Amyloid beta precursor protein.	Tumor necrosis factor receptor superfamily, member 21.	0.886
LOC111573543	APP	ENSAOCP00000022531	ENSAOCP00000003099	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta precursor protein.	0.725
LOC111573543	LOC111583303	ENSAOCP00000022531	ENSAOCP00000030051	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.942
LOC111573543	NCSTN	ENSAOCP00000022531	ENSAOCP00000018114	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.994
LOC111573543	psenen	ENSAOCP00000022531	ENSAOCP00000002996	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin enhancer, gamma-secretase subunit.	0.995
LOC111583303	APP	ENSAOCP00000030051	ENSAOCP00000003099	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta precursor protein.	0.725
LOC111583303	LOC111573543	ENSAOCP00000030051	ENSAOCP00000022531	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.942
LOC111583303	NCSTN	ENSAOCP00000030051	ENSAOCP00000018114	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Nicastrin.	0.994
LOC111583303	psenen	ENSAOCP00000030051	ENSAOCP00000002996	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin enhancer, gamma-secretase subunit.	0.995
LOC111585205	APP	ENSAOCP00000020398	ENSAOCP00000003099	Uncharacterized protein; Belongs to the synuclein family.	Amyloid beta precursor protein.	0.767
NCSTN	APP	ENSAOCP00000018114	ENSAOCP00000003099	Nicastrin.	Amyloid beta precursor protein.	0.909