Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prkraProtein kinase, interferon-inducible double stranded RNA dependent activator. (257 aa)    
Predicted Functional Partners:
dicer1
Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.
    
 0.990
drosha
Uncharacterized protein.
    
 0.910
LOC111579049
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 0.863
LOC111578592
Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.
    
 0.863
LOC111578586
Argonaute RISC component 1; Belongs to the argonaute family.
    
 0.863
lyar
Ly1 antibody reactive homolog (mouse).
   
 
 0.817
ENSAOCP00000000506
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.815
LOC111573734
Uncharacterized protein.
    
 0.815
ENSAOCP00000000530
Uncharacterized protein.
    
 0.815
ENSAOCP00000000547
Uncharacterized protein.
    
 0.815
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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