Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pmvkPhosphomevalonate kinase. (210 aa)    
Predicted Functional Partners:
mvk
Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
   
 0.994
mvd
Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.
   
 
 0.985
LOC111579328
3-hydroxy-3-methylglutaryl coenzyme A reductase.
    
 0.800
LOC111571978
Uncharacterized protein; Belongs to the FPP/GGPP synthase family.
   
 
 0.797
idi1
Isopentenyl-diphosphate delta isomerase 1.
   
 
 0.797
hmgcs1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.732
fdft1
Farnesyl-diphosphate farnesyltransferase 1.
   
  
 0.682
sqle
Squalene epoxidase a.
   
  
 0.672
LOC111565075
Cytochrome P450, family 51; Belongs to the cytochrome P450 family.
   
 0.672
dhcr7
7-dehydrocholesterol reductase.
   
 
 0.667
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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