node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSAOCP00000006048 | ENSAOCP00000020710 | ENSAOCP00000006048 | ENSAOCP00000020710 | PHD-type domain-containing protein. | Lysine (K)-specific demethylase 6B, b. | 0.429 |
ENSAOCP00000006048 | LOC111580106 | ENSAOCP00000006048 | ENSAOCP00000001394 | PHD-type domain-containing protein. | Nuclear receptor binding SET domain protein 2. | 0.412 |
ENSAOCP00000006048 | LOC111583696 | ENSAOCP00000006048 | ENSAOCP00000004420 | PHD-type domain-containing protein. | Tumor protein p53 binding protein, 1. | 0.465 |
ENSAOCP00000006048 | atm | ENSAOCP00000006048 | ENSAOCP00000019655 | PHD-type domain-containing protein. | Non-specific serine/threonine protein kinase. | 0.460 |
ENSAOCP00000006048 | kdm1a | ENSAOCP00000006048 | ENSAOCP00000027418 | PHD-type domain-containing protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.593 |
ENSAOCP00000006048 | pias4 | ENSAOCP00000006048 | ENSAOCP00000023704 | PHD-type domain-containing protein. | Protein inhibitor of activated STAT, 4a. | 0.455 |
ENSAOCP00000006048 | pwwp2a | ENSAOCP00000006048 | ENSAOCP00000029944 | PHD-type domain-containing protein. | PWWP domain containing 2A. | 0.450 |
ENSAOCP00000006048 | rnf168 | ENSAOCP00000006048 | ENSAOCP00000025786 | PHD-type domain-containing protein. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] | 0.447 |
ENSAOCP00000006048 | rnf8 | ENSAOCP00000006048 | ENSAOCP00000014440 | PHD-type domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.448 |
ENSAOCP00000006048 | znf217 | ENSAOCP00000006048 | ENSAOCP00000018509 | PHD-type domain-containing protein. | Zinc finger protein 217. | 0.429 |
ENSAOCP00000020710 | ENSAOCP00000006048 | ENSAOCP00000020710 | ENSAOCP00000006048 | Lysine (K)-specific demethylase 6B, b. | PHD-type domain-containing protein. | 0.429 |
ENSAOCP00000020710 | LOC111580106 | ENSAOCP00000020710 | ENSAOCP00000001394 | Lysine (K)-specific demethylase 6B, b. | Nuclear receptor binding SET domain protein 2. | 0.464 |
ENSAOCP00000020710 | kdm1a | ENSAOCP00000020710 | ENSAOCP00000027418 | Lysine (K)-specific demethylase 6B, b. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.463 |
LOC111580106 | ENSAOCP00000006048 | ENSAOCP00000001394 | ENSAOCP00000006048 | Nuclear receptor binding SET domain protein 2. | PHD-type domain-containing protein. | 0.412 |
LOC111580106 | ENSAOCP00000020710 | ENSAOCP00000001394 | ENSAOCP00000020710 | Nuclear receptor binding SET domain protein 2. | Lysine (K)-specific demethylase 6B, b. | 0.464 |
LOC111580106 | LOC111583696 | ENSAOCP00000001394 | ENSAOCP00000004420 | Nuclear receptor binding SET domain protein 2. | Tumor protein p53 binding protein, 1. | 0.649 |
LOC111580106 | atm | ENSAOCP00000001394 | ENSAOCP00000019655 | Nuclear receptor binding SET domain protein 2. | Non-specific serine/threonine protein kinase. | 0.610 |
LOC111580106 | pias4 | ENSAOCP00000001394 | ENSAOCP00000023704 | Nuclear receptor binding SET domain protein 2. | Protein inhibitor of activated STAT, 4a. | 0.572 |
LOC111580106 | pwwp2a | ENSAOCP00000001394 | ENSAOCP00000029944 | Nuclear receptor binding SET domain protein 2. | PWWP domain containing 2A. | 0.415 |
LOC111580106 | rnf168 | ENSAOCP00000001394 | ENSAOCP00000025786 | Nuclear receptor binding SET domain protein 2. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] | 0.578 |