Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rchy1Uncharacterized protein. (279 aa)    
Predicted Functional Partners:
polh
Polymerase (DNA directed), eta.
    
 0.994
LOC111577187
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.980
rps27a
Ribosomal protein S27a.
    
 0.975
ar
Androgen receptor.
    
 
 0.932
LOC111568069
Uncharacterized protein.
    
 
 0.912
LOC111582571
Ubiquitin-conjugating enzyme E2D 4 (putative); Belongs to the ubiquitin-conjugating enzyme family.
   
 0.856
UBE2D1
Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.822
LOC111581548
Ubiquitin-conjugating enzyme E2D 1a; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.807
LOC111586407
RING-type domain-containing protein; Belongs to the MDM2/MDM4 family.
    
 
 0.791
ENSAOCP00000023172
RING-type domain-containing protein.
    
 
 0.791
Your Current Organism:
Amphiprion ocellaris
NCBI taxonomy Id: 80972
Other names: A. ocellaris, clown anemonefish
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