Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
IbtkInhibitor of Bruton agammaglobulinemia tyrosine kinase. (1404 aa)    
Predicted Functional Partners:
LOC109194537
Ribonuclease P/MRP 25 subunit-like.
    
 
 0.959
CUL3
Cullin 3; Belongs to the cullin family.
   
 0.935
LOC109194151
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
 0.935
dnajc17
DnaJ (Hsp40) homolog, subfamily C, member 17.
      
 0.919
ENSONIP00000042235
Ribonuclease P protein subunit p25-like protein.
    
   0.771
LOC100693841
Eukaryotic translation initiation factor 4A1B; Belongs to the DEAD box helicase family.
    
   0.762
eif4a2
Eukaryotic translation initiation factor 4A, isoform 2; Belongs to the DEAD box helicase family.
    
   0.762
irak1bp1
Interleukin-1 receptor-associated kinase 1 binding protein 1.
      
 0.746
cul1
Cullin 1b; Belongs to the cullin family.
   
 0.732
I3JVM5_ORENI
CDK2 associated cullin domain 1; Belongs to the cullin family.
   
 0.708
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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