PLCB1 protein (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PLCB1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1239 aa)

Predicted Functional Partners:

PRKCB

0.932

LOC100697949

0.924

LOC100711838

0.924

DGKQ

0.911

gnb4

0.905

LOC100692028

0.905

LOC100706143

0.905

LOC100706405

0.905

LOC100697855

0.905

Itpr3

0.901

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DGKQ	LOC100697949	ENSONIP00000046828	ENSONIP00000018774	Diacylglycerol kinase.	Uncharacterized protein.	0.411
DGKQ	LOC100711838	ENSONIP00000046828	ENSONIP00000054089	Diacylglycerol kinase.	Guanine nucleotide-binding protein subunit alpha-14 isoform X1.	0.411
DGKQ	PLCB1	ENSONIP00000046828	ENSONIP00000001179	Diacylglycerol kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.911
Itpr3	PLCB1	ENSONIP00000051894	ENSONIP00000001179	Inositol 1,4,5-trisphosphate receptor, type 3.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.901
Itpr3	PRKCB	ENSONIP00000051894	ENSONIP00000052205	Inositol 1,4,5-trisphosphate receptor, type 3.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.928
LOC100692028	LOC100697855	ENSONIP00000005292	ENSONIP00000074888	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.613
LOC100692028	LOC100697949	ENSONIP00000005292	ENSONIP00000018774	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Uncharacterized protein.	0.813
LOC100692028	LOC100706143	ENSONIP00000005292	ENSONIP00000009535	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha 14.	0.609
LOC100692028	LOC100706405	ENSONIP00000005292	ENSONIP00000009536	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Uncharacterized protein.	0.609
LOC100692028	LOC100711838	ENSONIP00000005292	ENSONIP00000054089	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Guanine nucleotide-binding protein subunit alpha-14 isoform X1.	0.813
LOC100692028	PLCB1	ENSONIP00000005292	ENSONIP00000001179	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.905
LOC100692028	PRKCB	ENSONIP00000005292	ENSONIP00000052205	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.578
LOC100697855	LOC100692028	ENSONIP00000074888	ENSONIP00000005292	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.613
LOC100697855	LOC100697949	ENSONIP00000074888	ENSONIP00000018774	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Uncharacterized protein.	0.828
LOC100697855	LOC100706143	ENSONIP00000074888	ENSONIP00000009535	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Guanine nucleotide binding protein (G protein), alpha 14.	0.551
LOC100697855	LOC100706405	ENSONIP00000074888	ENSONIP00000009536	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Uncharacterized protein.	0.552
LOC100697855	LOC100711838	ENSONIP00000074888	ENSONIP00000054089	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Guanine nucleotide-binding protein subunit alpha-14 isoform X1.	0.828
LOC100697855	PLCB1	ENSONIP00000074888	ENSONIP00000001179	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.905
LOC100697855	gnb4	ENSONIP00000074888	ENSONIP00000002092	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	Guanine nucleotide binding protein (G protein), beta polypeptide 4b.	0.613
LOC100697949	DGKQ	ENSONIP00000018774	ENSONIP00000046828	Uncharacterized protein.	Diacylglycerol kinase.	0.411

page 1 of 4

Server load: low (12%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About