Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
trib2Tribbles pseudokinase 2. (345 aa)    
Predicted Functional Partners:
cop1
COP1 E3 ubiquitin ligase.
    
 
 0.825
appl1
Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.
    
 0.815
appl2
Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.
    
 0.815
Fosl2
Fos-like antigen 2.
   
 0.803
stk40
Serine/threonine kinase 40.
    
 
 0.765
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
 0.714
ENSONIP00000000047
RAC-gamma serine/threonine-protein kinase.
    
 0.708
LOC100707971
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.708
LOC100702193
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.708
akt1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.708
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.