Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdk12Cyclin-dependent kinase 12. (1351 aa)    
Predicted Functional Partners:
ccnk
Cyclin K; Belongs to the cyclin family.
   
 0.969
supt5h
Transcription elongation factor SPT5.
    
 0.948
polr2a
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.939
cdk9
Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.
    
 0.922
cdk7
Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.
   
0.893
ccnh
Cyclin H; Belongs to the cyclin family.
    
 0.875
LOC100709139
Cyclin T2b; Belongs to the cyclin family.
   
 0.864
LOC100698210
Cyclin T2; Belongs to the cyclin family.
   
 0.864
LOC100690070
Cyclin T1; Belongs to the cyclin family.
   
 0.864
mnat1
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
    
 0.849
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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