Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC100700177SH3 and cysteine rich domain 2. (417 aa)    
Predicted Functional Partners:
mysm1
Myb-like, SWIRM and MPN domains 1.
   
 0.798
ENSONIP00000038349
RING finger protein 223.
    
 0.722
ENSONIP00000000682
Intersectin 2a.
    
 0.662
I3KKD0_ORENI
Intersectin 2b.
    
 0.662
I3JR68_ORENI
NME/NM23 family member 8; Belongs to the NDK family.
   
 0.659
actl6a
Actin-like 6A; Belongs to the actin family.
   
 0.644
actr8
Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.
    
 0.628
dctn2
Dynactin 2 (p50).
    
 0.628
WDR1
WD repeat domain 1.
   
 0.626
ruvbl1
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
    
 0.624
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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