STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GADD45BRibosomal_L7Ae domain-containing protein. (153 aa)    
Predicted Functional Partners:
map3k4
Mitogen-activated protein kinase kinase kinase 4.
    
 0.953
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.946
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
  0.921
Cntd2
Cyclin N-terminal domain containing 2; Belongs to the cyclin family.
    
  0.916
ccnb3
Cyclin B3; Belongs to the cyclin family.
    
  0.916
ccnb1
Cyclin B1; Belongs to the cyclin family.
    
  0.916
LOC100692470
Cyclin B2; Belongs to the cyclin family.
    
  0.916
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
  0.916
cdk6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
  0.652
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
  0.652
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.