STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I3IXY4_ORENIMitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (805 aa)    
Predicted Functional Partners:
traf2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.866
map4k2
Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.859
I3JW29_ORENI
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.784
LOC100708442
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
  0.784
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
    
 0.603
mapk8ip2
Mitogen-activated protein kinase 8 interacting protein 2.
    
 0.603
grb2
Growth factor receptor-bound protein 2b.
   
 
 0.594
LOC100704732
Ras-related GTP binding A.
    
 
 0.546
map3k21
Mitogen-activated protein kinase kinase kinase.
    
 0.443
LOC100707946
Uncharacterized protein.
    
 0.443
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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