Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
arhgef33Rho guanine nucleotide exchange factor (GEF) 33. (808 aa)    
Predicted Functional Partners:
sting1
Stimulator of interferon genes protein.
   
 0.673
arhgef38
Rho guanine nucleotide exchange factor (GEF) 38.
   
 
 0.552
plekhg7
Pleckstrin homology domain containing, family G (with RhoGef domain) member 7.
    
 0.550
tp53bp1
Tumor protein p53 binding protein, 1.
    
 0.517
AFMID
Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
   
  
 0.498
trio
Trio Rho guanine nucleotide exchange factor a.
     
 0.483
LOC100700727
Uncharacterized protein.
     
 0.483
khk
Ketohexokinase.
      
 0.480
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11.
    
 0.447
ENSONIP00000000682
Intersectin 2a.
    
 0.438
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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