STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pdgfcPlatelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (364 aa)    
Predicted Functional Partners:
pdgfra
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
    
 0.989
tie1
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1.
    
 0.989
ENSONIP00000036848
Receptor-type tyrosine-protein kinase FLT3.
    
 0.986
pdgfrb
Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
    
 0.981
vegfc
Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.
     
 0.974
LOC100690958
Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family.
     
 0.966
Pdgfa
Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.
     
 0.966
Vegfd
Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.
     
 0.964
Vegfb
PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.
     
 0.964
I3KWA4_ORENI
PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.
     
 0.957
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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