Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
usp40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1290 aa)    
Predicted Functional Partners:
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.889
ENSONIP00000047919
Ubiquitin B.
   
 0.888
uvssa
UV-stimulated scaffold protein A.
    
 0.875
trip12
Thyroid hormone receptor interactor 12.
   
 
 0.874
daxx
Death-domain associated protein.
    
 0.864
gmps
Guanine monophosphate synthase.
   
 
 0.854
rps27a
Ribosomal protein S27a.
   
 0.824
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.812
dnmt1
DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
   
 
 0.787
anapc11
APC11 anaphase promoting complex subunit 11 homolog (yeast).
      
 0.764
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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