Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)    
Predicted Functional Partners:
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.993
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.993
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.993
e2f1
E2F transcription factor 1.
   
 0.990
rb1
Retinoblastoma 1.
   
 0.985
I3KQQ3_ORENI
Fizzy/cell division cycle 20 related 1b.
   
 0.981
FZR1
Fizzy/cell division cycle 20 related 1a.
   
 0.978
cdt1
Chromatin licensing and DNA replication factor 1.
   
 0.971
LOC102082412
Cyclin-dependent kinase inhibitor 1A.
   
 0.971
LOC100694127
WD_REPEATS_REGION domain-containing protein.
   
 0.970
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.