| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| I3KF05_ORENI | MCM7 | ENSONIP00000019700 | ENSONIP00000055028 | Uncharacterized protein. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.996 |
| I3KF05_ORENI | cdc45 | ENSONIP00000019700 | ENSONIP00000043787 | Uncharacterized protein. | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.969 |
| I3KF05_ORENI | cdc6 | ENSONIP00000019700 | ENSONIP00000000081 | Uncharacterized protein. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.998 |
| I3KF05_ORENI | cdt1 | ENSONIP00000019700 | ENSONIP00000016535 | Uncharacterized protein. | Chromatin licensing and DNA replication factor 1. | 0.999 |
| I3KF05_ORENI | mcm10 | ENSONIP00000019700 | ENSONIP00000014870 | Uncharacterized protein. | Minichromosome maintenance 10 replication initiation factor. | 0.984 |
| I3KF05_ORENI | mcm3 | ENSONIP00000019700 | ENSONIP00000057614 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
| I3KF05_ORENI | mcm4 | ENSONIP00000019700 | ENSONIP00000011994 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.996 |
| I3KF05_ORENI | mcm5 | ENSONIP00000019700 | ENSONIP00000010364 | Uncharacterized protein. | DNA helicase; Belongs to the MCM family. | 0.999 |
| I3KF05_ORENI | mcm8 | ENSONIP00000019700 | ENSONIP00000001739 | Uncharacterized protein. | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | 0.987 |
| I3KF05_ORENI | orc1 | ENSONIP00000019700 | ENSONIP00000009832 | Uncharacterized protein. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
| MCM7 | I3KF05_ORENI | ENSONIP00000055028 | ENSONIP00000019700 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Uncharacterized protein. | 0.996 |
| MCM7 | cdc45 | ENSONIP00000055028 | ENSONIP00000043787 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | CDC45 cell division cycle 45 homolog (S. cerevisiae). | 0.999 |
| MCM7 | cdc6 | ENSONIP00000055028 | ENSONIP00000000081 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.999 |
| MCM7 | cdt1 | ENSONIP00000055028 | ENSONIP00000016535 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Chromatin licensing and DNA replication factor 1. | 0.999 |
| MCM7 | mcm10 | ENSONIP00000055028 | ENSONIP00000014870 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Minichromosome maintenance 10 replication initiation factor. | 0.995 |
| MCM7 | mcm3 | ENSONIP00000055028 | ENSONIP00000057614 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM7 | mcm4 | ENSONIP00000055028 | ENSONIP00000011994 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM7 | mcm5 | ENSONIP00000055028 | ENSONIP00000010364 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA helicase; Belongs to the MCM family. | 0.999 |
| MCM7 | mcm8 | ENSONIP00000055028 | ENSONIP00000001739 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. | 0.990 |
| MCM7 | orc1 | ENSONIP00000055028 | ENSONIP00000009832 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.997 |
STRING v12.5 is now available!
