Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spred1Sprouty related EVH1 domain containing 1. (451 aa)    
Predicted Functional Partners:
Nf1
Neurofibromin 1b.
    
 0.888
ENSONIP00000045390
Ubiquitin thioesterase OTU1-like.
      
 0.702
LOC100690469
Ubiquitin thioesterase OTU1 isoform X1.
      
 0.702
egfl7
EGF-like-domain, multiple 7.
    
 
 0.673
hras
HRas proto-oncogene, GTPase a.
   
 0.649
elk4
ETS transcription factor ELK4.
      
 0.646
kras
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
   
 0.634
LOC100703836
Zgc:55558.
   
 0.634
psmd2
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 
 0.623
CSDE1
Cold shock domain containing E1, RNA-binding.
   
 0.603
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.