Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pak1Non-specific serine/threonine protein kinase. (669 aa)    
Predicted Functional Partners:
cdc42
Cell division cycle 42.
   
 0.985
PAK2
Non-specific serine/threonine protein kinase.
   
  0.974
pak2
Non-specific serine/threonine protein kinase.
   
  0.974
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.
   
 0.955
arhgef7
Rho guanine nucleotide exchange factor (GEF) 7a.
   
 0.955
LOC100696931
Rho guanine nucleotide exchange factor (GEF) 7b.
   
 0.955
nck1
Cytoplasmic protein.
    
 0.917
nck2
Cytoplasmic protein.
    
 0.917
map3k3
Mitogen-activated protein kinase kinase kinase 3.
    
 0.909
map3k2
Mitogen-activated protein kinase kinase kinase 2.
    
 0.909
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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