STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I3IYW8_ORENIRunt domain-containing protein. (290 aa)    
Predicted Functional Partners:
mysm1
Myb-like, SWIRM and MPN domains 1.
    
  0.938
cbfb
Core-binding factor subunit beta.
    
 0.924
yap1
Yes-associated protein 1.
    
 0.701
LOC100693896
Ets variant 2.
   
 0.657
ets1
V-ets avian erythroblastosis virus E26 oncogene homolog 1.
   
 0.657
I3KF85_ORENI
Uncharacterized protein.
   
 0.657
LOC100694653
Transforming growth factor beta; Belongs to the TGF-beta family.
   
 
 0.643
LOC109194259
T-cell acute lymphocytic leukemia 1.
    
 0.626
ENSONIP00000035341
T-cell acute lymphocytic leukemia protein 1 homolog.
    
 0.626
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.596
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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