Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
usp19Ubiquitin specific peptidase 19. (1517 aa)    
Predicted Functional Partners:
usp7
Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.
   
0.894
p53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.818
xpc
Xeroderma pigmentosum, complementation group C.
   
 
 0.798
ENSONIP00000047919
Ubiquitin B.
    
 0.794
I3IUU1_ORENI
Ring finger protein 123.
   
 0.787
usp14
Ubiquitin carboxyl-terminal hydrolase.
    
 
 0.749
USP15
Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family.
   
 
 0.733
trip12
Thyroid hormone receptor interactor 12.
    
 
 0.725
LOC100690902
Patatin-like phospholipase domain containing 2.
      
 0.698
wrap53
Telomerase Cajal body protein 1 isoform X1.
    
 0.668
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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