Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Setd4SET domain containing 4. (456 aa)    
Predicted Functional Partners:
kiaa1958
Uncharacterized protein KIAA1958 homolog.
      
 0.871
klhl23
Kelch-like family member 23.
   
  
 0.843
suclg2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.709
Setd9
SET domain-containing protein 9.
      
 0.709
get1
Guided entry of tail-anchored proteins factor 1.
      
 0.693
I3JR57_ORENI
FATP synthase c subunit lysine N-methyltransferase.
      
 0.687
LOC100702481
Family with sequence similarity 173 member A.
      
 0.678
Ppp1r8
Protein phosphatase 1, regulatory subunit 8b.
      
 0.675
mindy1
MINDY lysine 48 deubiquitinase 1.
    
 0.668
mmaa
Metabolism of cobalamin associated A.
    
 0.668
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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