Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mindy4Si:dkey-30h22.11. (694 aa)    
Predicted Functional Partners:
fam228b
Protein FAM228B isoform X3.
      
 0.657
ppp1r42
Protein phosphatase 1, regulatory subunit 42.
    
 
 0.430
gskip
Gsk3b interacting protein.
      
 0.419
sdhaf2
Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
      
 0.415
vps35l
VPS35 endosomal protein sorting factor like.
      
 0.413
I3JCM6_ORENI
Ubiquitinyl hydrolase 1.
      
 0.410
USP22
Ubiquitin carboxyl-terminal hydrolase.
      
 0.410
Selenoi
Selenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
      
 0.410
LOC100709542
General transcription factor IIIAa.
      
 0.405
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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